Sato A, Hashizume K, Onaya T, Miyakawa M, Makiuchi M
Endocrinol Jpn. 1976 Aug;23(4):319-25.
The effects of various concentrations of biogenic amines on the formation of adenosine-3', 5'-monophosphate (cyclic AMP) and their interactions with other thyroid stimulators were investigated in human thyroid slices from normal and Graves' disease. Most of biogenic amines were found to have the stimulatory effects to some extent. Among the biogenic amines tested, histamine was the most potent thyroid stimulator, norepinephrine and serotonin, the intermediate in terms of cyclic AMP formation. The effect of histamine was almost as potent as TSH in thyroid slices from Graves' disease. This stimulatory effect of histamine was blocked by metiamide, a histamine H2-receptor antagonist, but not by chlorpheniramine, a histamine H1-receptor antagonist. The effect of norepinephrine was completely inhibitied by propranolol, but not by phentolamine. Polyphloretin phosphate did not inhibit norepinephrine- or histamine-induced cyclic AMP formation, while it significantly depressed cyclic AMP formation induced by prostaglandin E2. The maximal effect of histamine was additive to that of TSH. It is suggested that biogenic amines, histamine and norepinephrine, in particular, have the thyroid receptors different from that of TSH or prostaglandin E2 and could play an important role in thyroid physiology.
在取自正常人和格雷夫斯病患者的人甲状腺切片中，研究了不同浓度的生物胺对3',5'-单磷酸腺苷（环磷酸腺苷）形成的影响及其与其他甲状腺刺激物的相互作用。发现大多数生物胺在一定程度上具有刺激作用。在所测试的生物胺中，组胺是最有效的甲状腺刺激物，去甲肾上腺素和5-羟色胺在环磷酸腺苷形成方面居于中等水平。在取自格雷夫斯病患者的甲状腺切片中，组胺的作用几乎与促甲状腺激素一样有效。组胺的这种刺激作用被组胺H2受体拮抗剂甲硫米特阻断，但未被组胺H1受体拮抗剂氯苯那敏阻断。去甲肾上腺素的作用被普萘洛尔完全抑制，但未被酚妥拉明抑制。聚磷酸根皮苷不抑制去甲肾上腺素或组胺诱导的环磷酸腺苷形成，而它能显著抑制前列腺素E2诱导的环磷酸腺苷形成。组胺的最大作用与促甲状腺激素的作用是相加的。提示生物胺，特别是组胺和去甲肾上腺素，具有与促甲状腺激素或前列腺素E2不同的甲状腺受体，并且可能在甲状腺生理学中起重要作用。
