Onaya T, Hashizume K, Sato A, Takazawa K, Akasu F
Endocrinology. 1977 Jan;100(1):61-6. doi: 10.1210/endo-100-1-61.
The existence of a histamine H2-receptor in the thyroid was investigated. Histamine in vitro stimulated the formation of cyclic AMP and colloid droplet formation in mouse thyroid lobes. Stimulation by histamine of cyclic AMP formation in mouse thyroid lobes was significantly inhibited by metiamide, a histamine H2-receptor antagonist. 4-Methylhistamine, a histamine H2-receptor agonist, markedly stimulated cyclic AMP formation, whereas 2-methylhistamine, a histamine H1-receptor agonist, was ineffective. The stimulation by 4-methylhistamine of cyclic AMP formation was markedly inhibited by metiamide, but not by chlorpheniramine, a histamine H1-receptor antagonist. In contrast, metiamide did not affect cyclic AMP formation induced either by TSH or by the long-acting thyroid stimulator. Therefore, it is suggested that there exists a histamine H2-receptor in the membranes of the thyroid follicular cells which facilitate thyroid hormone secretion via the adenylate cyclase-cyclic AMP system.
对甲状腺中组胺H2受体的存在进行了研究。组胺在体外刺激小鼠甲状腺叶中环状AMP的形成和胶体小滴的形成。组胺H2受体拮抗剂甲硫咪特显著抑制组胺对小鼠甲状腺叶中环状AMP形成的刺激。组胺H2受体激动剂4-甲基组胺显著刺激环状AMP的形成，而组胺H1受体激动剂2-甲基组胺则无效。甲硫咪特显著抑制4-甲基组胺对环状AMP形成的刺激，但组胺H1受体拮抗剂氯苯那敏则无此作用。相反，甲硫咪特不影响促甲状腺激素或长效甲状腺刺激素诱导的环状AMP形成。因此，提示甲状腺滤泡细胞膜中存在组胺H2受体，其通过腺苷酸环化酶-环状AMP系统促进甲状腺激素分泌。
