Stawerska Renata, Smyczynska Joanna, Hilczer Maciej, Lewinski Andrzej, Karasek Michal
Department of Pediatric Endocrinology, Chair of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland.
Neuro Endocrinol Lett. 2008 Dec;29(6):889-94.
In normal conditions, prolactin (Prl) secretion manifests a circadian pattern. So far, there have only been but few studies, concerning intrasubject variability and repeatability of the circadian Prl secretion pattern, based on pulse analysis. It seems, that macroscopic analysis based on measurement of Prl concentration at nine time points every 3 hours during 24 hours is an appropriate method to assess Prl profile for clinical purposes. The aim of the study was to assess the repeatability of that circadian Prl secretion pattern in a group of short children without hormonal disorders.
The analysis comprised the results of two circadian Prl profiles, performed from 2 to 14 months in 23 prepubertal children (16 boys) with idiopathic short stature, aged: 10.3+/-2.4 yrs.
There were no statistical differences between Prl concentrations at the same time points in the two consecutive profiles, but the comparison of Prl concentrations at 8:00 gave results which were close to the border of statistical significance (p=0.055), what indicated low repeatability of measurement results at that particular time point. There were no statistical differences between the values of particular parameters in macroscopic profile analysis in the first and in the second test.
Circadian Prl profile, based on nine Prl concentration measurements, taken every 3 hours during one day, is characterized by high repeatability of the results and low intrasubject variability in children, despite the results of Prl concentration at 08:00 o'clock.
在正常情况下，催乳素（Prl）分泌呈现昼夜节律模式。到目前为止，基于脉冲分析，关于昼夜Prl分泌模式的个体内变异性和可重复性的研究很少。似乎，基于在24小时内每3小时在九个时间点测量Prl浓度的宏观分析是评估临床目的Prl概况的合适方法。本研究的目的是评估一组无激素紊乱的矮小儿童中昼夜Prl分泌模式的可重复性。
分析包括23名青春期前特发性矮小儿童（16名男孩）在2至14个月内进行的两次昼夜Prl概况分析结果，年龄为10.3±2.4岁。
两个连续概况中同一时间点的Prl浓度之间无统计学差异，但8:00时Prl浓度的比较结果接近统计学显著性边界（p = 0.055），这表明该特定时间点测量结果的可重复性较低。第一次和第二次测试中宏观概况分析中特定参数的值之间无统计学差异。
基于一天中每3小时进行九次Prl浓度测量的昼夜Prl概况，其结果具有高可重复性，且儿童个体内变异性低，尽管8:00时Prl浓度的结果有所不同。
