Deng L, Wu Z-N, Han P-Z
School of Life Science, Shenzhen University, Shenzhen, Guangdong Province, China.
Int J Neurosci. 2009;119(2):291-304. doi: 10.1080/00207450802328250.
The present study investigated the effects of food restriction (FR) on memory and the expression of synapsin I in the brain of young mice. The results showed that 20% FR did not retard the body weight gain of mice, while the 60% and 80% FR reduced the mice's body weight. The memory after 24 hr of learning was not changed by FR, whereas long-term memory was improved significantly in 20% FR mice. In addition, 60% and 80% FR did not impair the mice's memory. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% FR, and down-regulated by 60% and 80% FR.
本研究调查了食物限制（FR）对幼鼠记忆力及大脑中突触素I表达的影响。结果显示，20%的食物限制并未延缓小鼠体重增加，而60%和80%的食物限制则使小鼠体重减轻。学习24小时后的记忆力不受食物限制影响，而20%食物限制组小鼠的长期记忆力显著提高。此外，60%和80%的食物限制并未损害小鼠的记忆力。20%的食物限制使小鼠大脑中突触素I的转录表达上调，而60%和80%的食物限制则使其下调。
