Herman B H, Nagy Z M
Dev Psychobiol. 1977 Jan;10(1):65-75. doi: 10.1002/dev.420100110.
Mice selected for high (H), medium (M), and low (L) brain weight were trained to the goal arm opposite their preference in a shock-escape T-maze at 7, 9, 11, or 13 days of age. Twenty-four hours later, half of the trained groups at each age received additional training to the original goal, whereas the other half was trained to the opposite goal. Maturational control groups without prior training were trained on the selected retest days for the previously trained groups. Improvement in correct choice-point turns during training was suggested for the H-line by 9 days of age and by 11 days of age for the M- and L-lines. During retraining, H-line mice demonstrated 24-hr retention effects by 10 days of age, whereas 24-hr memory was not indicated for M- and L-lines at any of the ages investigated. These results indicate that the onsets of learning and memory were influenced by genes affecting brain weight, in that H-line mice demonstrated more rapid brain growth as well as heavier brain weights at every age studied as compared with M- and L-line mice which showed similar brain growth functions.
选择脑重量高（H）、中（M）和低（L）的小鼠，在7、9、11或13日龄时，在电击逃避T型迷宫中训练它们走向与偏好相反的目标臂。24小时后，每个年龄组中一半经过训练的小鼠接受额外训练，使其回到原来的目标，而另一半则被训练走向相反的目标。未经过预先训练的成熟对照组在之前经过训练的组所选择的重新测试日进行训练。H系小鼠在9日龄时，M系和L系小鼠在11日龄时，训练期间正确选择点转弯的能力有所提高。在重新训练期间，H系小鼠在10日龄时表现出24小时的记忆保留效应，而在所研究的任何年龄，M系和L系小鼠均未表现出24小时记忆。这些结果表明，学习和记忆的开始受到影响脑重量的基因的影响，因为与表现出相似脑生长功能的M系和L系小鼠相比，H系小鼠在每个研究年龄都表现出更快的脑生长以及更重的脑重量。
