Cornelis Pierre, Matthijs Sandra, Van Oeffelen Liesbeth
Department of Molecular and Cellular Interactions, Laboratory of Microbial Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium.
Biometals. 2009 Feb;22(1):15-22. doi: 10.1007/s10534-008-9193-0. Epub 2009 Jan 8.
The Pseudomonas genus belongs to the gamma division of Proteobacteria and many species produce the characteristic yellow-green siderophore pyoverdine, and often a second siderophore, of lower affinity for iron. These bacteria are known for their ability to colonize different ecological niches and for their versatile metabolism. It is therefore not surprising that they are endowed with the capacity to take up exogenous xenosiderophores via different TonB-dependent receptors. Uptake of iron is controlled by the central regulator Fur, and via extracytoplasmic sigma factors or other types of regulators (two-component systems, AraC regulators). In this review the Fur regulon (experimentally proven and/or predicted) of P. aeruginosa will be presented. An interesting feature revealed by this analysis of Fur-regulated genes is the overlap between the iron and the sulfur regulons as well with the quorum sensing system.
假单胞菌属属于变形菌门γ-变形菌纲，许多物种会产生特征性的黄绿色铁载体绿脓菌素，并且通常还会产生第二种对铁亲和力较低的铁载体。这些细菌以其定殖于不同生态位的能力和多样的代谢而闻名。因此，它们具有通过不同的依赖TonB的受体摄取外源异源铁载体的能力也就不足为奇了。铁的摄取受中央调节因子Fur控制，并通过胞外σ因子或其他类型的调节因子（双组分系统、AraC调节因子）进行调控。在本综述中，将介绍铜绿假单胞菌的Fur调控子（经实验证实和/或预测的）。对Fur调控基因的这一分析揭示的一个有趣特征是铁调控子与硫调控子以及群体感应系统之间的重叠。
