AMR-Research Laboratory, Department of Biological Sciences, Adamas University, Barasat-Barrackpore Rd, Kolkata, 700126, India.
Department of Microbiology Lady Brabourne College, Kolkata, 700017, India.
World J Microbiol Biotechnol. 2024 Jul 20;40(9):270. doi: 10.1007/s11274-024-04076-x.
Bacterial pigments stand out as exceptional natural bioactive compounds with versatile functionalities. The pigments represent molecules from distinct chemical categories including terpenes, terpenoids, carotenoids, pyridine, pyrrole, indole, and phenazines, which are synthesized by diverse groups of bacteria. Their spectrum of physiological activities encompasses bioactive potentials that often confer fitness advantages to facilitate the survival of bacteria amid challenging environmental conditions. A large proportion of such pigments are produced by bacterial pathogens mostly as secondary metabolites. Their multifaceted properties augment potential applications in biomedical, food, pharmaceutical, textile, paint industries, bioremediation, and in biosensor development. Apart from possessing a less detrimental impact on health with environmentally beneficial attributes, tractable and scalable production strategies render bacterial pigments a sustainable option for novel biotechnological exploration for untapped discoveries. The review offers a comprehensive account of physiological role of pigments from bacterial pathogens, production strategies, and potential applications in various biomedical and biotechnological fields. Alongside, the prospect of combining bacterial pigment research with cutting-edge approaches like nanotechnology has been discussed to highlight future endeavours.
细菌色素作为具有多种功能的特殊天然生物活性化合物脱颖而出。这些色素代表了来自不同化学类别的分子，包括萜类、类萜、类胡萝卜素、吡啶、吡咯、吲哚和吩嗪，它们由不同的细菌群合成。它们的生理活性谱包括生物活性潜能，这些潜能通常赋予细菌在挑战性环境条件下生存的优势。此类色素中的很大一部分是由细菌病原体主要作为次级代谢产物产生的。它们多方面的特性增加了在生物医学、食品、制药、纺织、油漆、生物修复和生物传感器开发等领域的潜在应用。除了具有对健康的不利影响较小且具有环境有益的特性外，可处理和可扩展的生产策略使细菌色素成为探索未开发发现的新型生物技术的可持续选择。该综述全面介绍了细菌病原体色素的生理作用、生产策略以及在各种生物医学和生物技术领域的潜在应用。此外，还讨论了将细菌色素研究与纳米技术等前沿方法相结合的前景，以突出未来的努力。
