利用近交系近亲品系鉴定运动激活和焦虑的数量性状基因座。
Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains.
作者信息
Bailey J S, Grabowski-Boase L, Steffy B M, Wiltshire T, Churchill G A, Tarantino L M
机构信息
Genomics Institute of the Novartis Research Foundation, Department of Genetics, San Diego, CA, USA.
出版信息
Genes Brain Behav. 2008 Oct;7(7):761-9. doi: 10.1111/j.1601-183x.2008.00415.x.
Abstract
We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.
摘要
我们使用旷场试验（一种在啮齿动物中成熟的焦虑相关行为模型），在两个表型相似的近交小鼠品系C57BL/6J和C58/J中进行了数量性状基因座（QTL）定位实验。这个杂交最初是作为乙基亚硝基脲诱变定位研究的对照杂交进行的。令人惊讶的是，尽管这两个品系的旷场行为相似，但我们在它们的F2后代中鉴定出了显著的QTL。标记回归确定了8号染色体上的一个位点与多种旷场测量指标相关，以及13号和17号染色体上的位点之间存在显著的相互作用。8号染色体位点和相互作用效应共同构成了控制这些行为的QTL核心集，在一部分行为中还存在1号和6号染色体上的其他位点。
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