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Naloxone enhances the release of acetylcholine from cholinergic interneurons of the striatum if the dopaminergic input is impaired.

作者信息

Sándor N T, Kiss J, Sándor A, Lendvai B, Vizi E S

机构信息

Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.

出版信息

Brain Res. 1991 Jun 28;552(2):343-5. doi: 10.1016/0006-8993(91)90102-2.

DOI:10.1016/0006-8993(91)90102-2
PMID:1913196
Abstract

Naloxone significantly enhanced the release of radioactive acetylcholine ([3H]ACh) from rat striatal slices loaded with [3H]choline either when the nigrostriatal pathway had been destroyed by 6-hydroxydopamine or when the D2 dopamine receptors had been inhibited by sulpiride. This in vitro study supplies the first neurochemical evidence, that, in addition to D2-receptor-mediated dopaminergic tonic control, there is opiate-receptor mediated presynaptic modulation of striatal ACh release, possibly by endogenous enkephalin released from local neurons. Such modulation occurs under conditions in which the dopaminergic input is impaired.

摘要

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