Alberch J, Marsal J, Solsona C
Brain Res. 1985 Nov 4;346(2):353-6. doi: 10.1016/0006-8993(85)90869-8.
The dopaminergic modulation of the acetylcholine release from rat striatal slices has been investigated using a chemiluminescent method. Dopamine, more efficiently than apomorphine, decreased the potassium-evoked release of acetylcholine. The effect of dopamine antagonists, haloperidol and sulpiride, has been studied, and haloperidol was a better antagonist than sulpiride to the dopamine effect. Haloperidol elicited an acetylcholine release from striatal slices at 0.1 nM, probably by removing endogenous dopamine from dopaminergic receptors.
利用化学发光法研究了多巴胺能对大鼠纹状体切片乙酰胆碱释放的调节作用。多巴胺比阿扑吗啡更有效地降低了钾离子诱发的乙酰胆碱释放。研究了多巴胺拮抗剂氟哌啶醇和舒必利的作用，氟哌啶醇对多巴胺作用的拮抗效果优于舒必利。氟哌啶醇在0.1 nM时可引起纹状体切片释放乙酰胆碱，可能是通过去除多巴胺能受体上的内源性多巴胺来实现的。
