Corsini Marcelo Soeiro, Faraco Fátima N, Castro Alessandra A Pereira, Onuma Tatiana, Sendyk Wilson R, Shibli Jamil Awad
Department of Peridontics and Implantology, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
J Oral Implantol. 2008;34(6):298-302. doi: 10.1563/1548-1336-34.6.298.
The aim of this study was to evaluate the effect of intermittent administration of human parathyroid hormone [rhPTH (1-34)] on the removal torque of implants placed in rabbit tibiae. Twenty male New Zealand rabbits were submitted to implant surgery. Each animal received one machined screw-type implant (3.75 mm diameter x 8 mm length) in the proximal metaphysis of the right tibia. The rabbits were then divided into 2 groups: the test group (n = 10) received 6 microg/kg of rhPTH (1-34) subcutaneously in the dorsal region 3 days a week, and the control group (n = 10) received placebo. Removal torque was performed at 28 and 56 days after implant placement for both groups. The mean removal torque values at 28 days were 37.0 +/- 4.36 Ncm and 47.4 +/- 6.77 Ncm for control and test groups respectively (P < .05). At 56 days the reverse torque was 45.8 +/- 3.96 Ncm for the control group and 55.8 +/- 2.86 Ncm for the test group, indicating that the removal torque was significantly higher in the test groups (P < .05). These results demonstrated that intermittent treatment with rhPTH (1-34) enhanced the removal torque of implants in rabbit tibiae.
本研究的目的是评估间歇性给予人甲状旁腺激素[rhPTH(1 - 34)]对植入兔胫骨的种植体去除扭矩的影响。20只雄性新西兰兔接受了种植手术。每只动物在右胫骨近端干骺端植入一枚机械加工的螺钉型种植体（直径3.75 mm×长度8 mm）。然后将兔子分为2组：试验组（n = 10）每周3天在背部皮下注射6 μg/kg的rhPTH(1 - 34)，对照组（n = 10）接受安慰剂。两组在种植体植入后28天和56天进行去除扭矩测试。对照组和试验组在28天时的平均去除扭矩值分别为37.0±4.36 Ncm和47.4±6.77 Ncm（P < 0.05）。在56天时，对照组的反向扭矩为45.8±3.96 Ncm，试验组为55.8±2.86 Ncm，表明试验组的去除扭矩显著更高（P < 0.05）。这些结果表明，rhPTH(1 - 34)的间歇性治疗增强了兔胫骨种植体的去除扭矩。
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