Huh Jisun, Jung Ui-Won, Park Kyeong-Mee, Kim Hyun Sil, Kim Kee-Deog, Park Wonse
Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
Department of Periodontology, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
Biomed Res Int. 2017;2017:6087676. doi: 10.1155/2017/6087676. Epub 2017 Feb 9.
This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH ( = 10) or saline ( = 10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 g/kg/day. Radiographic and histomorphometric analyses were performed. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.
本研究评估了给予间歇性甲状旁腺激素[PTH(1 - 34)，以下简称PTH]对健康兔上颌窦提升早期骨愈合的影响。将牛骨矿物质植入20只雌性新西兰白兔的鼻窦。动物被随机分为两组，PTH组(n = 10)和生理盐水组(n = 10)，其中PTH组或生理盐水组每周皮下注射5天，共2周。每组动物的一半在术后2周处死，另一半在术后4周处死。PTH的剂量为10μg/kg/天。进行了影像学和组织形态计量学分析。PTH组和生理盐水组的新骨面积(NBA)无显著差异。PTH组在整个植骨区域以及划定窗口、中心和施氏膜区域的NBA从2周龄到4周龄显著增加。两组破骨细胞数量从2周龄到4周龄均显著减少，两组之间无差异。在愈合的前4周，间歇性PTH可能不会刺激健康兔的新骨形成。
