Mandal Kalyaneswar, Pentelute Brad L, Tereshko Valentina, Kossiakoff Anthony A, Kent Stephen B H
Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
J Am Chem Soc. 2009 Feb 4;131(4):1362-3. doi: 10.1021/ja8077973.
Racemic protein crystallography, enabled by total chemical synthesis, has allowed us to determine the X-ray structure of native scorpion toxin BmBKTx1; direct methods were used for phase determination. This is the first example of a protein racemate that crystallized in space group I41/a.
通过全化学合成实现的外消旋蛋白质晶体学,使我们能够确定天然蝎子毒素BmBKTx1的X射线结构;采用直接法进行相位测定。这是在外消旋蛋白质晶体学中,首次在空间群I41/a中结晶的实例。