黑色素瘤生物学与斑马鱼的前景。
Melanoma biology and the promise of zebrafish.
作者信息
Ceol Craig J, Houvras Yariv, White Richard M, Zon Leonard I
机构信息
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Zebrafish. 2008 Dec;5(4):247-55. doi: 10.1089/zeb.2008.0544.
Abstract
Advantageous organismal and technical attributes of the zebrafish are being increasingly applied to study cancer biology. Along with other tumor models, zebrafish that develop melanomas have been generated. In both genetics and phenotype, zebrafish melanomas are strikingly similar to their human counterparts. For this reason, studies in the zebrafish are poised to make significant contributions to melanoma biology. In this review, we summarize important features of human melanoma and discuss how the zebrafish can be used to address many questions that remain unanswered about this devastating disease.
摘要
斑马鱼有利的机体和技术特性正越来越多地应用于癌症生物学研究。与其他肿瘤模型一样，已经培育出了会发生黑色素瘤的斑马鱼。在遗传学和表型方面，斑马鱼黑色素瘤与人类黑色素瘤都极为相似。因此，对斑马鱼的研究有望为黑色素瘤生物学做出重大贡献。在这篇综述中，我们总结了人类黑色素瘤的重要特征，并讨论了如何利用斑马鱼来解决有关这种毁灭性疾病的许多尚未得到解答的问题。
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