Park Dongkook, Taghert Paul H
Department of Anatomy & Neurobiology, Washington University Medical School, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.
Gen Comp Endocrinol. 2009 May 15;162(1):2-7. doi: 10.1016/j.ygcen.2008.12.012. Epub 2008 Dec 24.
This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.
本综述探讨了转录因子DIMMED在昆虫神经分泌细胞调控中所起作用的相关证据。遗传学、解剖学和分子学数据均表明，DIMMED是调节性分泌途径的专门调控因子。DIMM通常在多种表达神经肽的细胞中表达，且似乎与神经分泌细胞命运高度相关。DIMM缺失与神经肽及神经肽相关酶表达缺陷有关。DIMM的增加可促进肽能细胞中的此类表达，并可将这种神经分泌特性赋予传统神经元。我们对为解释DIMMED如何调节这些基本细胞特性而提出的模型进行了综述。
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