Bediou Benoit, Eimer Martin, d'Amato Thierry, Hauk Olaf, Calder Andrew J
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK.
Neuropsychologia. 2009 Feb;47(3):825-34. doi: 10.1016/j.neuropsychologia.2008.12.012. Epub 2008 Dec 14.
Individual differences in reward-drive have been associated with increased attention toward facial signals of aggression, heightened experience of anger and vulnerability to display aggressive behaviour. Recent fMRI research suggests that these effects rely on reduced ventromedial prefrontal (and increased amygdala) response to aggressive facial displays compared with neutral and sad expressions in subjects scoring high on reward-drive. However, nothing is known about the timing of this modulation. Using event-related potentials (ERPs), we provide the first evidence that greater proneness to display hostile and aggressive behaviour (measured by high scores on the reward-drive) is associated with a reduced midline frontocentral response to aggressive faces within 200-300ms. In addition to confirming a particular interaction between anger processing and aggression related personality traits in ventromedial prefrontal brain regions, our study brings a first indication of when their interaction occurs in the brain, strengthening results from previous classical as well as functional connectivity fMRI studies.
奖励驱动方面的个体差异与对攻击性面部信号的注意力增加、愤怒体验增强以及表现攻击性行为的易感性有关。最近的功能磁共振成像研究表明，与奖励驱动得分高的受试者在面对中性和悲伤表情时相比，这些影响依赖于腹内侧前额叶（以及杏仁核活动增强）对攻击性面部表情的反应减弱。然而，对于这种调节的时间尚不清楚。利用事件相关电位（ERP），我们首次提供证据表明，更倾向于表现出敌意和攻击性行为（通过奖励驱动得分高来衡量）与200 - 300毫秒内对攻击性面孔的中线额中央反应减弱有关。除了证实腹内侧前额叶脑区在愤怒处理和与攻击相关的人格特质之间存在特定相互作用外，我们的研究首次表明了它们在大脑中相互作用的时间，强化了先前经典以及功能连接功能磁共振成像研究的结果。
