The University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
Fertil Steril. 2010 Mar 1;93(4):1169-72. doi: 10.1016/j.fertnstert.2008.11.025. Epub 2009 Jan 9.
To evaluate the impact of clomiphene citrate on vision.
Observational study.
Patients were referred to the University of Ottawa Eye Institute ophthalmology clinic from the Department of Obstetrics and Gynaecology of the Ottawa Hospital-General Campus.
PATIENT(S): Eight adult females taking clomiphene citrate and experiencing visual disturbances.
INTERVENTION(S): Patients received a comprehensive visual evaluation twice: once during a washout period, and once during an active clomiphene citrate treatment.
MAIN OUTCOME MEASURE(S): Ophthalmologic examination, color vision, visual acuity, contrast sensitivity, visual fields using standard automated perimetry, and foveal flicker sensitivity at high (32 Hz) and low (8 Hz) temporal frequencies.
RESULT(S): We found no differences between the washout and clomiphene citrate conditions for color vision, visual acuity, contrast sensitivity, and visual fields. The only statistically significant difference was found for foveal flicker sensitivity at 32 Hz in the right eye, with a similar trend in the left eye and at 8 Hz in both eyes.
CONCLUSION(S): The effect of clomiphene citrate on vision was minimal, and the visual disturbances were reversible in all patients. A bilateral reduction in flicker sensitivity was the only observed visual disturbance. Women who experience visual symptoms associated with clomiphene citrate should be monitored, but therapy can usually be maintained.
评估枸橼酸氯米酚对视力的影响。
观察性研究。
患者从渥太华医院综合校区妇产科转至渥太华大学眼科研究所眼科诊所。
8 名成年女性服用枸橼酸氯米酚并出现视觉障碍。
患者接受了两次全面的视觉评估：一次是在洗脱期，一次是在枸橼酸氯米酚的治疗期。
眼科检查、色觉、视力、对比敏感度、标准自动视野计检查的视野以及高（32 Hz）和低（8 Hz）时间频率下的中央凹闪烁敏感度。
我们发现色觉、视力、对比敏感度和视野在洗脱期和枸橼酸氯米酚治疗期之间没有差异。唯一具有统计学意义的差异是右眼中央凹闪烁敏感度在 32 Hz 时，左眼和双眼在 8 Hz 时也有类似的趋势。
枸橼酸氯米酚对视力的影响很小，所有患者的视觉障碍都是可逆的。唯一观察到的视觉障碍是闪烁敏感性的双侧降低。服用枸橼酸氯米酚出现视觉症状的女性应接受监测，但通常可以维持治疗。
