20例原发性前列腺肿瘤培养物的细胞遗传学评估。

Cytogenetic evaluation of 20 cultured primary prostatic tumors.

作者信息

Brothman A R, Peehl D M, Patel A M, MacDonald G R, McNeal J E, Ladaga L E, Schellhammer P F

机构信息

Department of Pediatrics, Eastern Virginia Medical School, Norfolk 23507.

出版信息

Cancer Genet Cytogenet. 1991 Aug;55(1):79-84. doi: 10.1016/0165-4608(91)90238-p.

DOI:10.1016/0165-4608(91)90238-p

PMID:1913611

Abstract

We report the cytogenetic evaluation of 20 cultured cell strains derived from primary prostatic adenocarcinomas obtained from radical prostatectomies. The majority of the strains contained cells with only normal male karyotypes (46,XY), but cytogenetically abnormal clonal populations were found in five strains. Two of those strains contained aberrations involving the Y chromosome, one with a -Y and one with a +Y. Three strains (one of which also had the XYY karyotype) exhibited cells with double-minute chromosomes and four strains contained near tetraploid cells.

摘要

我们报告了对20株培养细胞系的细胞遗传学评估，这些细胞系源自根治性前列腺切除术中获取的原发性前列腺腺癌。大多数细胞系仅包含具有正常男性核型（46,XY）的细胞，但在5个细胞系中发现了细胞遗传学异常的克隆群体。其中两个细胞系含有涉及Y染色体的畸变，一个是-Y，另一个是+Y。三个细胞系（其中一个也具有XYY核型）表现出带有双微体染色体的细胞，四个细胞系含有近四倍体细胞。