Melikoglu M A, Melikoglu M, Gurbuz U, Budak B S, Kacar C
Department of Rheumatology, Physical Medicine and Rehabilitation, School of Medicine, Akdeniz University, Antalya, Turkey.
J Clin Pharm Ther. 2008 Dec;33(6):699-701. doi: 10.1111/j.1365-2710.2008.00955.x.
The antimalarials are one of the most commonly prescribed drugs in medical practice, for conditions such as rheumatoid arthritis as well as malaria. They are generally well-tolerated and the possible side effects of synthetic antimalarials, though infrequent, are well known. Besides the familiar adverse reactions, a localized mucocutaneous bluish-grey to black discolouration can sometimes be seen with antimalarial drugs. The aim of this report was to draw attention to the localized mucocutaneous bluish-grey hyperpigmentation induced by hydroxychloroquine with a case presentation and a review of the literature.
