de Andrade Bruno Augusto Benevenuto, Fonseca Felipe Paiva, Pires Fábio Ramôa, Mesquita Ana Terezinha Marques, Falci Saulo Gabriel Moreira, Dos Santos Silva Alan Roger, Vargas Pablo Agustin, Jorge Jacks, de Almeida Oslei Paes
Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas UNICAMP, Piracicaba, São Paulo, Brazil.
J Cutan Pathol. 2013 Sep;40(9):833-8. doi: 10.1111/cup.12182. Epub 2013 Jun 19.
Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.
在医疗实践中，抗疟药常用于治疗类风湿性关节炎、红斑狼疮以及疟疾等病症。它们通常耐受性良好，但副作用虽不常见却广为人知。抗疟药磷酸氯喹可能会导致口腔黏膜出现蓝灰色至黑色的色素沉着，主要出现在硬腭上。在本报告中，我们描述了另外五例与长期使用磷酸氯喹相关的腭部色素沉着病例。专业人员必须了解抗疟药如磷酸氯喹的不良反应，以便对患者做出正确诊断和适当处理。抗疟药引起的口腔色素沉着的早期诊断可能具有重要意义，因为它可能是眼部受累的早期迹象，因此有助于预防患者抗疟治疗的进一步并发症。
