Erb Klaus J
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riss, 88440, Germany.
Trends Immunol. 2009 Feb;30(2):75-82. doi: 10.1016/j.it.2008.11.005. Epub 2009 Jan 8.
Recent epidemiological and experimental data indicate that infection with helminths can protect humans from the development of allergic disorders by immunosuppressive mechanisms that involve the induction of IL-10 and/or regulatory T cells. Furthermore, helminth-derived immune modulators suppress allergic responses in mice. Trichuris suis therapy has been shown to be safe and efficacious in treating inflammatory bowel disease in humans. Has the time come to treat patients who have allergic diseases or healthy humans who are at risk of developing these diseases with helminths or helminth-derived products? Here, I discuss the pros and cons of such an approach.
最近的流行病学和实验数据表明，感染蠕虫可通过涉及诱导白细胞介素-10和/或调节性T细胞的免疫抑制机制，保护人类免受过敏性疾病的侵害。此外，蠕虫衍生的免疫调节剂可抑制小鼠的过敏反应。猪鞭虫疗法已被证明在治疗人类炎症性肠病方面是安全有效的。是时候用蠕虫或蠕虫衍生产品来治疗患有过敏性疾病的患者或有患这些疾病风险的健康人了吗？在此，我将讨论这种方法的利弊。
