INSERM University Lille 2, Lille, France.
Allergy. 2011 Jul;66 Suppl 95:16-8. doi: 10.1111/j.1398-9995.2011.02624.x.
Vertebrates and helminths have co-evolved for 500 million years, developing mutual adaptation mechanisms between parasites and hosts. Today, however, helminth diseases are among the most neglected communicable diseases. Epidemiological evidence shows that exposure to helminth parasites is inversely correlated with allergy incidence, and helminths induce immune hyporeactivity in both the innate and adaptive systems. The mechanisms include parasite-derived regulatory molecules, the study of which opens new avenues for the control of allergic and autoimmune diseases.
脊椎动物和寄生虫已经共同进化了 5 亿年，在寄生虫和宿主之间发展出了相互适应的机制。然而，如今寄生虫病是最被忽视的传染病之一。流行病学证据表明，接触寄生虫与过敏症的发生率呈反比，寄生虫会在先天和适应性免疫系统中引起免疫反应低下。其机制包括寄生虫衍生的调节分子，对这些分子的研究为控制过敏和自身免疫性疾病开辟了新途径。
