Liska V, Vitvarová I
Ocní oddĕlení NsP, Litomysl, OUNZ Svitavy.
Cesk Oftalmol. 1991 Mar;47(2):133-7.
The authors give an account of a 57-year-old male patient who was regularly dialyzed for two years and treated because of suspect TB of the spine with antituberculotics, incl. ethambutol. In the course of 8-9 months he was given 17.9 mg/kg ethambutol per day. Because of the practically zero excretion by the damaged kidney the drug cumulated in the serum and reached toxic levels before dialysis. Gradual deterioration of eyesight developed (central acuity and colour sense) which resulted in bilateral atrophy of the optic nerves with concentric narrowing of the visual field.
作者报告了一名57岁男性患者，该患者接受了两年的定期透析治疗，并因疑似脊柱结核接受抗结核药物治疗，包括乙胺丁醇。在8 - 9个月的时间里，他每天服用17.9毫克/千克的乙胺丁醇。由于受损肾脏几乎无排泄功能，药物在血清中蓄积，在透析前达到中毒水平。视力逐渐下降（中心视力和色觉），导致双侧视神经萎缩，视野呈同心性缩小。
