脂多糖A及相关化合物。二十六。脂多糖A的生物活性五-O-乙酰基-N-糖基神经氨酸基-和五-O-乙酰基-3-脱氧-D-半乳糖-2-壬酮糖醛酸-(α2→6)-D-葡糖胺-4-磷酸类似物的合成。
Lipid A and related compounds. XXVI. Syntheses of biologically active penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-galacto-2- nonulopyranosonic acid-(alpha 2----6)-D-glucosamine-4-phosphate analogs of lipid A.
作者信息
Ikeda K, Kawai K, Achiwa K
机构信息
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1991 May;39(5):1305-9. doi: 10.1248/cpb.39.1305.
The syntheses of novel penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid-(alpha 2----6)-D-glucosamine-4-phosphate analogues of lipid A containing sialic acid in place of 3-deoxy-D-manno-2-octulosonic acid are described. Preliminary examination of the biological activity revealed that two synthetic disaccharides showed mitogenic activities and weak antitumor activities.
描述了新型五 - O - 乙酰基 - N - 糖基神经氨酸基和五 - O - 乙酰基 - 3 - 脱氧 - D - 甘油 - D - 半乳糖 - 2 - 壬酮糖醛酸 -（α2→6）- D - 葡萄糖胺 - 4 - 磷酸类似物脂多糖A的合成，其中唾液酸取代了3 - 脱氧 - D - 甘露糖 - 2 - 辛酮糖酸。对生物活性的初步研究表明，两种合成二糖具有促有丝分裂活性和较弱的抗肿瘤活性。
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