脂多糖A及相关化合物。二十九。与脂多糖A结构相关的具有生物活性的含N-酰化L-天冬酰胺的D-葡萄糖胺衍生物的合成。
Lipid A and related compounds. XXIX. Synthesis of biologically active N-acylated L-asparagine-containing D-glucosamine derivatives structurally related to lipid A.
作者信息
Suhara Y, Arakawa M, Ikeda K, Achiwa K
机构信息
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2526-31. doi: 10.1248/cpb.42.2526.
PMID:7697768
Abstract
New beta-N-acylated L-asparagine-linked D-glucosamine derivatives, in which the reducing unit of lipid A has been mimicked by a lipoamino acid, have been synthesized. Compounds 1 and 2 exhibit mitogenicity and nitric oxide (NO) productivity.
摘要
已经合成了新的β-N-酰化L-天冬酰胺连接的D-葡糖胺衍生物，其中脂质A的还原单元已被脂氨基酸模拟。化合物1和2表现出促有丝分裂活性和一氧化氮（NO）生成能力。
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