Lin N, Liang P
Electron Microscopy Laboratory, Fujian Medical College, Fuzhou.
Zhonghua Bing Li Xue Za Zhi. 1991 Jun;20(2):113-5.
Megakaryocytes in 42 cases of Chronic Myeloproliferative Disorders were studied pathologically, and a classification of these disorders was suggested. Abnormal megakaryocytes were classified as immature, mature, naked-nuclear, micro-, giant, multinucleated and dysplastic types based on the degree of maturity, the number of ploidy, and the presence or absence of atypia. Immunohistochemical studies indicated that antibodies against platelet glycoprotein Ib, IIb/IIIa as well as VIII R:Ag are highly specific for the detection of megakaryocytes, especially the morphologically unrecognizable ones. With regard to the identification of micromegakaryocytes, nuclear size, shape and degree of cytoplasmic maturity were emphasized. In addition to the classification, the clinic-pathological significance of abnormal megakaryocytes is discussed.
对42例慢性骨髓增殖性疾病的巨核细胞进行了病理研究，并提出了这些疾病的分类。异常巨核细胞根据成熟程度、倍体数量以及是否存在异型性分为未成熟型、成熟型、裸核型、微型、巨型、多核型和发育异常型。免疫组织化学研究表明，抗血小板糖蛋白Ib、IIb/IIIa以及VIII R:Ag的抗体对巨核细胞的检测具有高度特异性，尤其是形态上无法识别的巨核细胞。关于微型巨核细胞的识别，强调了核大小、形状和细胞质成熟程度。除了分类外，还讨论了异常巨核细胞的临床病理意义。
