Dediol Emil, Luksić Ivica, Virag Miso
Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia.
Coll Antropol. 2008 Oct;32 Suppl 2:199-202.
Tumors of the lip are squamous cell carcinomas in 95% of the cases. Also, in 95% of the cases they arise on a vermilion of the lower lip, because of greater exposure of the lower lip vermilion to direct, cumulative UV radiation which is main etiologic factor in development of squamous cell carcinoma. We have reviewed patients that have been treated for lower lip carcinoma at the Department for Maxillofacial surgery, University hospital "Dubrava", from 1990 to 2007. Most common surgical procedure was V-shaped excision of the lip with or without vermilionectomy. For more extensive tumors we used some of the reconstruction methods with local or distant flaps (Webster-Bernard, Karapandzić, free flap). Neck dissection was performed only in patients with clinically evident metastasis or large carcinoma. Although regional metastasis is rare, it significantly lowers five-year survival. Also, we found worse outcome in patients that have been treated previously elsewhere and came for surgical therapy because of recurrent/residual tumor or neck metastasis in comparison to those that were initially treated at the Department of Maxillofacial surgery.
95%的唇部肿瘤为鳞状细胞癌。此外，95%的病例发生在下唇的唇红部，这是因为下唇唇红部更多地暴露于直接、累积的紫外线辐射下，而紫外线辐射是鳞状细胞癌发生的主要病因。我们回顾了1990年至2007年期间在“杜布拉瓦”大学医院颌面外科接受下唇癌治疗的患者。最常见的手术方法是V形唇部切除术，可伴有或不伴有唇红切除术。对于范围更广的肿瘤，我们采用了一些局部或远处皮瓣的重建方法（韦伯斯特-伯纳德法、卡拉潘齐克法、游离皮瓣）。仅对有临床明显转移或大肿瘤的患者进行颈部清扫。尽管区域转移很少见，但它会显著降低五年生存率。此外，我们发现，与最初在颌面外科接受治疗的患者相比，那些先前在其他地方接受过治疗、因复发/残留肿瘤或颈部转移而来接受手术治疗的患者预后更差。
