Lo Russo D, Agostini V, Frosini P
Istituto di Clinica Otorinolaringoiatrica, IIa Cattedra, dell'Università di Firenze.
Acta Otorhinolaryngol Ital. 1990 Sep-Oct;10(5):447-51.
Carcinoma of the lip is a common lesion which is not always acknowledged as as a potentially lethal disease. The risk of cancer occurs most commonly among aging white men. The risk factors normally associated with lip cancer are rural residence and outdoor occupation. In addition, both actinic radiation and tobacco smoking have been considered casually related to lip cancer. The present study is based on a retrospective review of 86 patients (82 males, 4 females, mean age 65) affected by carcinoma of the lip, treated in Florence from 1970 to 1988. The most frequent site for carcinoma of the lip proved to be the lower lip (71 cases); other sites included the upper lip (7) and the commissure (8). The lip tumor was a squamous cell carcinoma in 82 patients and a basal cell carcinoma in the remaining four. Good prognosis was found for all those with relatively small lesions (T1-T2). On the contrary, the prognosis proved quite poor for those who exhibited tumor fixation to the mandible or erosion of the mandible (23.5%, 5 year survival). Primary radiotherapy may be used for the smaller lesions as cure rates proved equivalent to those achieved surgically although the authors found surgery is always preferable as a primary method of treatment. Surgical excision of the tumor is a relatively minor procedure with a minimum of morbidity as compared with radiation therapy which may lead to local tissue reaction and may disturb function. Surgical management is also recommended as it bears the advantage of being to give a histologically accurate tumor margin assessment. Moreover, with surgery, functional results are good.(ABSTRACT TRUNCATED AT 250 WORDS)
唇癌是一种常见病变,但人们并不总是将其视为一种潜在的致命疾病。癌症风险最常出现在老年白人男性中。通常与唇癌相关的风险因素是居住在农村和从事户外职业。此外,光化辐射和吸烟都被认为与唇癌有偶然关联。本研究基于对1970年至1988年在佛罗伦萨接受治疗的86例唇癌患者(82例男性,4例女性,平均年龄65岁)的回顾性分析。结果表明,唇癌最常见的部位是下唇(71例);其他部位包括上唇(7例)和口角(8例)。82例患者的唇肿瘤为鳞状细胞癌,其余4例为基底细胞癌。所有病变相对较小(T1 - T2)的患者预后良好。相反,那些肿瘤固定于下颌骨或下颌骨有侵蚀的患者预后相当差(5年生存率为23.5%)。对于较小的病变可采用原发性放疗,因为治愈率与手术相当,不过作者认为手术作为主要治疗方法总是更可取的。与可能导致局部组织反应并可能影响功能的放射治疗相比,肿瘤的手术切除是一个相对较小的手术,发病率最低。推荐手术治疗还因为它具有能在组织学上准确评估肿瘤边缘的优势。此外,手术的功能效果良好。(摘要截取自250词)