分子伞运输：经典尺寸/亲脂性规则的例外情况。
Molecular umbrella transport: exceptions to the classic size/lipophilicity rule.
作者信息
Mehiri Mohamed, Chen Wen-Hua, Janout Vaclav, Regen Steven L
机构信息
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
出版信息
J Am Chem Soc. 2009 Feb 4;131(4):1338-9. doi: 10.1021/ja806476t.
Abstract
The ability of a series of molecular umbrellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to cross fluid liposomal membranes made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) (95/5, mol/mol) has been determined. In sharp contrast to the classic "size/lipophilicity" rule of membrane transport, those molecular umbrellas that were larger in size and less lipophilic crossed these liposomal membranes more readily. The likely origin for this unusual behavior is briefly discussed.
摘要
已测定了一系列由胆酸、L-赖氨酸、亚精胺和级联蓝衍生而来的分子伞穿过由1-棕榈酰-2-油酰基-sn-甘油-3-磷酸胆碱（POPC）/1-棕榈酰-2-油酰基-sn-甘油-3-磷脂酰甘油（POPG）（95/5，摩尔/摩尔）制成的流体脂质体膜的能力。与经典的膜转运“大小/亲脂性”规则形成鲜明对比的是，那些尺寸较大且亲脂性较低的分子伞更容易穿过这些脂质体膜。本文简要讨论了这种异常行为的可能起源。
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