Liu Huo-Wang, He Guang-Xiang, Sun Hong
Department of Otorhinolaryngology-Head & Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Dec;33(12):1119-22.
To observe the expression of human beta-defensin-1 (hBD-1) and human beta-defensin-2 (hBD-2) in recurrent nasal polyps, and to investigate the role of beta-defensin in the recurrent nasal polyps.
Tissues of nasal polyps was obtained from 10 patients with nasal polyps undergoing endoscopic sinus surgery, recurrent nasal polyps from 10 patients 6 months after surgery, nasal mucosa from 10 recovered patients with nasal polyps postoperatively and,10 control subjects. hBD-1 mRNA and hBD-2 mRNA levels of tissue specimens in all groups were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).
There was no significant difference in hBD-1 mRNA level between the 4 groups (P>0.05). Expression of hBD-2 mRNA was detected in patients with nasal polyps and recurrent nasal polyps, but rare in the recovered patients and the control subjects.
hBD-1 is a constitutive expression and hBD-2 is an induced expression. beta-Defensin may play an important role in forming the nasal polyps.
观察人β-防御素-1（hBD-1）和人β-防御素-2（hBD-2）在复发性鼻息肉中的表达情况，探讨β-防御素在复发性鼻息肉中的作用。
选取10例接受鼻内镜鼻窦手术的鼻息肉患者的鼻息肉组织、术后6个月复发鼻息肉患者的复发性鼻息肉组织、10例鼻息肉术后恢复患者的鼻黏膜组织以及10例对照者的组织。采用逆转录聚合酶链反应（RT-PCR）检测所有组组织标本中hBD-1 mRNA和hBD-2 mRNA水平。
4组之间hBD-1 mRNA水平差异无统计学意义（P>0.05）。在鼻息肉患者和复发性鼻息肉患者中检测到hBD-2 mRNA表达，但在恢复患者和对照者中罕见。
hBD-1为组成性表达，hBD-2为诱导性表达。β-防御素可能在鼻息肉形成中起重要作用。
