[ toll样受体信号通路在伴鼻息肉的慢性鼻-鼻窦炎中的表达 ]
[Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps].
作者信息
Wang Xin, Zhao Chunyuan, Liu Ming
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical Universitry, Harbin,150086, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Dec;23(23):1059-62.
OBJECTIVE
To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.
METHOD
Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.
RESULT
Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.
CONCLUSION
The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.
目的
探讨Toll样受体（TLRs）信号通路在伴鼻息肉的慢性鼻-鼻窦炎（CRS）中的表达情况。
方法
采用基因芯片分析检测伴鼻息肉的CRS中TLRs信号通路的表达。
结果
在19个差异表达（两倍变化）的基因中，4个基因上调，15个基因下调。
结论
TLRs信号通路中差异表达的基因可能在CRS的发病机制中发挥作用。此外，TLR9及其激动剂的作用需要进一步研究。
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