Leroy Claire, Bragulat Véronique, Berlin Ivan, Grégoire Marie-Claude, Bottlaender Michel, Roumenov Dimitri, Dollé Frédéric, Bourgeois Sandrine, Penttilä Jani, Artiges Eric, Martinot Jean-Luc, Trichard Christian
INSERM U797, Research Unit Neuroimaging and Psychiatry, Orsay, France.
J Clin Psychopharmacol. 2009 Feb;29(1):86-8. doi: 10.1097/JCP.0b013e31819e98f.
The inhibition of cerebral monoamine oxidases (MAOs) by cigarette smoke components could participate to the tobacco addiction. However, the actual extent of this inhibition in vivo in smokers is still poorly known. We investigated cerebral MAO-A availability in 7 tobacco-dependent subjects and 6 healthy nonsmokers, using positron emission tomography (PET) and the MAO-A selective radioligand [C]befloxatone. In comparison to nonsmokers, smokers showed a significant overall reduction of [C]befloxatone binding potential (BP) in cortical areas (average reduction, -60%) and a similar trend in caudate and thalamus (-40%). Our findings confirm a widespread inhibition of cerebral MAO-A in smokers. This mechanism may contribute to tobacco addiction and for a possible mood-modulating effect of tobacco.
香烟烟雾成分对脑内单胺氧化酶（MAOs）的抑制作用可能与烟草成瘾有关。然而，吸烟者体内这种抑制作用的实际程度仍知之甚少。我们使用正电子发射断层扫描（PET）和MAO - A选择性放射性配体[C]贝氟沙酮，对7名烟草依赖者和6名健康非吸烟者的脑内MAO - A可用性进行了研究。与非吸烟者相比，吸烟者在皮质区域[C]贝氟沙酮结合潜能（BP）显著降低（平均降低-60%），尾状核和丘脑也有类似趋势（-40%）。我们的研究结果证实吸烟者脑内MAO - A受到广泛抑制。这种机制可能导致烟草成瘾，并可能产生烟草对情绪的调节作用。
