Smith Dylan M, Fisher Derek, Blier Pierre, Ilivitsky Vadim, Knott Verner
University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
Department of Psychology, Mount Saint Vincent University, Halifax, NS, Canada.
J Psychopharmacol. 2016 Jan;30(1):56-62. doi: 10.1177/0269881115613518. Epub 2015 Nov 4.
While nicotine is often associated with the neuropsychological effects of tobacco smoke, the robust monoamine oxidase (MAO) inhibition observed in chronic smokers is also likely to play a role. Electroencephalographically-indexed alterations in baseline neural oscillations by nicotine have previously been reported in both smokers and non-smokers, however, little is known about the effects of MAO inhibition in combination with nicotine on resting state EEG. In a sample of 24 healthy non-smoking males, the effects of 6 mg nicotine gum, as well as MAO-A inhibition via 75 mg moclobemide, were investigated in separate and combined conditions over four separate test sessions. Drug effects were observed in the alpha2, beta2, and theta band frequencies. Nicotine increased alpha2 power, and moclobemide decreased beta2 power. Theta power was decreased most robustly by the combination of both drugs. Therefore, this study demonstrated that the nicotinic and MAO inhibiting properties of tobacco may differentially influence fast-wave oscillations (alpha2 and beta2), while acting in synergy to influence theta oscillations.
虽然尼古丁通常与烟草烟雾的神经心理效应相关，但在慢性吸烟者中观察到的强大的单胺氧化酶（MAO）抑制作用也可能起作用。此前在吸烟者和非吸烟者中均有报道，尼古丁会使基线神经振荡发生脑电图指标改变，然而，关于MAO抑制与尼古丁联合使用对静息态脑电图的影响却知之甚少。在24名健康非吸烟男性样本中，在四个单独的测试环节中，分别以及联合使用6毫克尼古丁口香糖和通过75毫克吗氯贝胺抑制MAO-A的效果进行了研究。在α2、β2和θ频段观察到了药物效果。尼古丁增加了α2功率，吗氯贝胺降低了β2功率。两种药物联合使用时，θ功率下降最为显著。因此，本研究表明，烟草的尼古丁和MAO抑制特性可能对快波振荡（α2和β2）产生不同影响，同时协同作用影响θ振荡。
