Vigo Daniel V
Instituto de Investigaciones Farmacológicas (ININFA).
Vertex. 2008 Jul-Aug;19(80):201-10.
During part of the past century any reference to genetics as cause for psychiatric disorders was vetoed, favouring explanations based on the environment as pathogen. Later and as a backlash, science seemed to bet on the sufficiency of the genetic level to understand pathology. Currently, in keeping with the consolidation of the neuroscientific paradigm, a higher level of complexity has been achieved and has rendered new models, such as gene-environment interaction and correlation, which allow for a more rigorous understanding of how the human phenotype displays itself in the world. Profound transformations in the field of mental health can be foreseen as a result of the new paradigm.
在上个世纪的一段时间里,任何将遗传学视为精神疾病病因的观点都被否决了,人们更倾向于基于环境是病原体的解释。后来,作为一种反弹,科学似乎押注于基因层面足以理解病理学。目前,随着神经科学范式的巩固,已经实现了更高层次的复杂性,并产生了新的模型,如基因-环境相互作用和相关性,这使得人们能够更严格地理解人类表型在世界上是如何表现的。由于新范式,心理健康领域有望发生深刻变革。