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[关于精神疾病的遗传或环境本质的争论的最新情况]

[An update on the debate about the genetic or environmental nature of psychiatric disorders].

作者信息

Vigo Daniel V

机构信息

Instituto de Investigaciones Farmacológicas (ININFA).

出版信息

Vertex. 2008 Jul-Aug;19(80):201-10.

PMID:19142244
Abstract

During part of the past century any reference to genetics as cause for psychiatric disorders was vetoed, favouring explanations based on the environment as pathogen. Later and as a backlash, science seemed to bet on the sufficiency of the genetic level to understand pathology. Currently, in keeping with the consolidation of the neuroscientific paradigm, a higher level of complexity has been achieved and has rendered new models, such as gene-environment interaction and correlation, which allow for a more rigorous understanding of how the human phenotype displays itself in the world. Profound transformations in the field of mental health can be foreseen as a result of the new paradigm.

摘要

在上个世纪的一段时间里,任何将遗传学视为精神疾病病因的观点都被否决了,人们更倾向于基于环境是病原体的解释。后来,作为一种反弹,科学似乎押注于基因层面足以理解病理学。目前,随着神经科学范式的巩固,已经实现了更高层次的复杂性,并产生了新的模型,如基因-环境相互作用和相关性,这使得人们能够更严格地理解人类表型在世界上是如何表现的。由于新范式,心理健康领域有望发生深刻变革。

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