Kas M J H, Fernandes C, Schalkwyk L C, Collier D A
Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
Mol Psychiatry. 2007 Apr;12(4):324-30. doi: 10.1038/sj.mp.4001979. Epub 2006 Nov 21.
Family and twin studies have revealed that genetic factors play a major role in psychiatric disorders, however, attempts to find susceptibility genes for these complex disorders have been largely unsuccessful. Therefore, new research strategies are required to tackle the complex interactions of genes, developmental, and environmental events. Here, we will address a behavioural domain concept that focuses on the genetics of behavioural domains relevant to both animal behaviour and across human psychiatric disorders. We believe that interspecies trait genetics rather than complex syndrome genetics will optimize genotype-phenotype relationships for psychiatric disorders and facilitate the identification of biological substrates underlying these disorders.
家族和双胞胎研究表明，遗传因素在精神疾病中起主要作用，然而，寻找这些复杂疾病易感基因的尝试大多未成功。因此，需要新的研究策略来应对基因、发育和环境事件之间的复杂相互作用。在此，我们将探讨一个行为领域概念，该概念聚焦于与动物行为及人类精神疾病相关的行为领域遗传学。我们认为，种间性状遗传学而非复杂综合征遗传学将优化精神疾病的基因型-表型关系，并有助于识别这些疾病潜在的生物学基础。
