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射频消融治疗骨样骨瘤-5 年经验。

Radiofrequency ablation in the treatment of osteoid osteoma-5-year experience.

机构信息

Institute of Clinical Radiology, Ludwig Maximilians-University, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany.

出版信息

Eur J Radiol. 2010 Feb;73(2):374-9. doi: 10.1016/j.ejrad.2008.11.018. Epub 2009 Jan 13.

Abstract

PURPOSE

This study aimed to determine the success and complication rates of radiofrequency ablation (RFA) in treatment of osteoid osteoma (OO) and duration of pain relief. Furthermore value of bone biopsy prior to the RFA was evaluated.

MATERIALS AND METHODS

Within 61 months 39 patients (23 male, 16 female, 7-53 years, mean 18.7 years, median 17 years) suffering from osteoid osteoma were treated. Lesions were located in femur (n=20), tibia (n=10), spine (n=5), humerus (n=1), radius (n=1), talus (n=1) and pelvis (n=1). In children, RFA was performed under general anaesthesia, in adults conscious sedation was preferred. In 29 of 39 (74%) lesion biopsies were obtained. Cooling of skin was performed in OOs located in bones with minor soft tissue covering (tibia, radius) and saline flushing via an additional needle was performed if the OO was adjacent to nerval structures. Primary success rate, complications, symptom-free interval, follow-up and biopsy results were evaluated.

RESULTS

Within observation period (1-61 months; median: 32 months) 38 of 39 patients were successfully treated and had no more complaints. In 3 of 38 patients relapse occurred after 1, 14 and 32 months and RFA was repeated. Two major complications (broken drill, infection) and 2 minor complications (hematoma, prolonged pain) were observed. Biopsy was able to prove diagnosis in 14 of 29 (48%) cases.

CONCLUSIONS

Biopsy prior to treatment is not mandatory due to a remarkable amount of false negative findings in clinically and morphologically unambiguous cases of OO. RFA is a highly effective, efficient, minimally invasive and safe method for the treatment of OO.

摘要

目的

本研究旨在确定射频消融(RFA)治疗骨样骨瘤(OO)的成功率和并发症发生率以及疼痛缓解的持续时间。此外,还评估了 RFA 前骨活检的价值。

材料与方法

在 61 个月内,对 39 名(23 名男性,16 名女性;7-53 岁,平均 18.7 岁,中位数 17 岁)患有骨样骨瘤的患者进行了治疗。病变位于股骨(n=20)、胫骨(n=10)、脊柱(n=5)、肱骨(n=1)、桡骨(n=1)、距骨(n=1)和骨盆(n=1)。儿童患者在全身麻醉下进行 RFA,成人患者则首选清醒镇静。在 39 例病变中有 29 例(74%)进行了活检。对于骨皮质覆盖软组织较少的 OO(胫骨、桡骨),进行皮肤冷却;对于邻近神经结构的 OO,则通过额外的针进行盐水冲洗。评估了主要成功率、并发症、无症状间隔、随访和活检结果。

结果

在观察期(1-61 个月;中位数:32 个月)内,39 例患者中有 38 例成功治疗且无任何不适。在 38 例患者中有 3 例复发,复发时间分别为 1、14 和 32 个月,再次进行了 RFA。观察到 2 例主要并发症(钻头断裂、感染)和 2 例次要并发症(血肿、疼痛延长)。在 29 例活检中有 14 例(48%)能够明确诊断。

结论

对于临床和形态学上明确的 OO 病例,由于大量假阴性结果,治疗前进行活检并非强制性要求。RFA 是一种治疗 OO 的高效、有效、微创且安全的方法。

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