Guerra A, Pastor J C
Instituto de Oftalmobiología Aplicada, Facultad de Medicina, Universidad de Valladolid, Spain.
Curr Eye Res. 1991 Aug;10(8):697-701. doi: 10.3109/02713689109013863.
Retinal cryoapplication accelerates blood resorption of experimental vitreous hemorrhages shortening the time until fundus visualization is possible. For the animals that underwent cryoapplication five days after blood injection into the vitreous cavity, the mean time to fundus visualization was 3.75 weeks versus 5.06 weeks for the control group (p less than 0.001). Retinal cryoapplication also causes an increase in the concentration of fibrin degradation products in the vitreous cavity, indicating an activation of fibrinolysis, one of the most important processes involved in hemorrhage resolution. Use of topical indomethacin slightly lessens the effect of cryoapplication on acceleration of blood resorption (mean 4.06 weeks until visualization), but does not influence the effect on fibrinolysis.
视网膜冷冻疗法可加速实验性玻璃体出血的血液吸收，缩短直至眼底可视化的时间。对于在玻璃体腔注射血液五天后接受冷冻疗法的动物，眼底可视化的平均时间为3.75周，而对照组为5.06周（p小于0.001）。视网膜冷冻疗法还会导致玻璃体腔中纤维蛋白降解产物浓度增加，表明纤维蛋白溶解被激活，这是出血吸收过程中最重要的过程之一。局部使用吲哚美辛会稍微减轻冷冻疗法对加速血液吸收的效果（可视化的平均时间为4.06周），但不影响对纤维蛋白溶解的作用。
