Yakimovskii A F, Varshavskaja V M, Yakubenko A L
Department of Normal Physiology, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg, Russia.
Bull Exp Biol Med. 2008 Aug;146(2):165-7. doi: 10.1007/s10517-008-0241-0.
Magnesium chloride injected into rat rostral neostriatum before picrotoxin prevents motor hyperactivity induced by this GABAA receptor antagonist: prevents the increase in spontaneous motor activity in the open field test and reduces reproduction and duration of choreic hyperkinesia. Injection of magnesium 15 min after picrotoxin virtually did not modify the hyperkinetic effects of picrotoxin. The results indicate the role of calcium processes in the appearance of strial picrotoxin hyperactivity and principal possibility of its correction with magnesium only before the cascade of respective calcium ionic transformations is triggered in the brain.
在给予印防己毒素之前，向大鼠吻侧新纹状体注射氯化镁可预防这种GABAA受体拮抗剂诱发的运动亢进：在旷场试验中可预防自发运动活动增加，并减少舞蹈病性运动增多的再现和持续时间。在给予印防己毒素15分钟后注射镁，实际上不会改变印防己毒素的运动亢进作用。结果表明钙过程在纹状体印防己毒素运动亢进出现中的作用，以及仅在大脑中引发相应钙离子转化级联反应之前用镁纠正这种运动亢进的主要可能性。
