Iakimovskiĭ A F
Biull Eksp Biol Med. 1993 Jul;116(7):9-10.
The effects of three-week daily intrastriatal 5 micrograms picrotoxine microinjections (m.i.) and influences of preceding similar haloperidol, metoclopramide (5 micrograms) or amphetamine (15 micrograms) m.i. in rats were investigated. The oro-facial dyskinesia and intensive choreo-myoclonic limb jerks (with the distinct generalization) after the picrotoxine m.i. were prevented by metoclopramide and party inhibited by haloperidol intrastriatal m.i. No hyperkinetic stimulant effects of amphetamine were registered, on the contrary--some inhibiting effect of its m.i. 20-24 hours before picrotoxin were observed. The role of the striatal GABA and dopamine systems in neuromotor dyskinesias and their functional relationship are discussed.
研究了连续三周每日向大鼠纹状体内微量注射5微克印防己毒素的效果，以及之前类似地向纹状体内微量注射氟哌啶醇、甲氧氯普胺（5微克）或苯丙胺（15微克）的影响。甲氧氯普胺可预防印防己毒素微量注射后出现的口面部运动障碍和强烈的舞蹈样肌阵挛性肢体抽搐（伴有明显的泛化），氟哌啶醇纹状体内微量注射可部分抑制上述症状。未观察到苯丙胺的运动亢进刺激作用，相反，在印防己毒素注射前20 - 24小时微量注射苯丙胺有一定的抑制作用。文中讨论了纹状体γ-氨基丁酸和多巴胺系统在神经运动障碍中的作用及其功能关系。
