组织色素对大鼠大脑产前暴露于硝酸铅延迟效应严重程度的影响。

Effect of histochrome on the severity of delayed effects of prenatal exposure to lead nitrate in the rat brain.

作者信息

Ryzhavsky B Ya, Lebedko O A, Belolubskaya D S

机构信息

Department of Histology, Far-Eastern State Medical University, Khabarovsk, Russia.

出版信息

Bull Exp Biol Med. 2008 Aug;146(2):267-71. doi: 10.1007/s10517-008-0263-7.

DOI:10.1007/s10517-008-0263-7

PMID:19145334

Abstract

The effects of histochrome on the severity of delayed effects of prenatal exposure to lead nitrate were studied in the rat brain. Exposure of pregnant rats to lead nitrate during activation of free radical oxidation reduced activity of NADH- and NADPH-dehydrogenases in cortical neurons of their 40-day-old progeny, reduced the number of neurons in a visual field, increased the number of pathologically modified neurons, and stimulated rat motor activity in an elevated plus-maze. Two intraperitoneal injections of histochrome in a dose of 0.1 mg/kg before and after lead citrate challenge attenuated the manifestations of oxidative stress and prevented the changes in some morphological and histochemical parameters of the brain, developing under the effect of lead exposure.

摘要

研究了组织色素对产前暴露于硝酸铅延迟效应严重程度的影响，实验对象为大鼠大脑。在自由基氧化激活过程中，怀孕大鼠暴露于硝酸铅，导致其40日龄后代皮质神经元中NADH和NADPH脱氢酶的活性降低，视野中神经元数量减少，病理改变的神经元数量增加，并在高架十字迷宫中刺激大鼠的运动活动。在柠檬酸铅攻击前后，腹腔注射两次剂量为0.1mg/kg的组织色素，可减轻氧化应激的表现，并防止在铅暴露影响下大脑某些形态学和组织化学参数的变化。