Ryzhavskiĭ B Ia, Lebed'ko O A, Beloliubskaia D S, Baranova S N
Morfologiia. 2007;131(1):27-31.
Administration of a single dose of lead nitrate (200 mg/kg) to pregnant rats (Day 18 of gestation) resulted in the appearance of destructive brain changes in their offspring on postnatal Day 40, including the cysts, foci of glial cell proliferation, pyknosis of neurons, decrease of NADH- and NADPH-diaphorase activity in neocortical and hippocampal neurons. The reduction of both neuronal density in the cortex and cortical thickness was also demonstrated. The intensity of free radical oxidation in the cortex was increased 3-fold, while the concentration of lipid hydroperoxides was increased 3.9 times, and the resistance to peroxidation was decreased by a factor of 3, which is indicative of oxidative stress. Possible mechanisms of the pathological changes development are discussed.
给妊娠大鼠（妊娠第18天）单次注射硝酸铅（200毫克/千克），结果其后代在出生后第40天出现了脑部破坏性变化，包括囊肿、胶质细胞增殖灶、神经元固缩、新皮质和海马神经元中NADH和NADPH黄递酶活性降低。还证实了皮质中神经元密度和皮质厚度均降低。皮质中自由基氧化强度增加了3倍，而脂质氢过氧化物浓度增加了3.9倍，抗过氧化能力降低了3倍，这表明存在氧化应激。文中讨论了病理变化发展的可能机制。
