Hindocha Sandip, McGrouther Duncan Angus, Bayat Ardeshir
Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocenter, University of Manchester, 131 Princess St, Manchester M1 7DN, England, UK.
Hand (N Y). 2009 Sep;4(3):256-69. doi: 10.1007/s11552-008-9160-9. Epub 2009 Jan 15.
Dupuytren's Disease (DD) is a common, fibroproliferative disorder affecting the palmar surface of the hands which is often irreversible and progressive. Understanding the epidemiology of DD is important in order to provide clues to its etiopathogenesis. This review aims to evaluate the epidemiological studies carried out in DD since 1951. Studies evaluating the epidemiology of DD were searched using Medline, Pubmed, and Scopus which dated back from 1951 to current date. Inclusion criteria were any studies investigating the prevalence or incidence of DD in any population group. A total of 620 articles were cited. Forty-nine studies were subsequently identified as relevant to evaluating the epidemiology of DD. The prevalence of DD in all studies increased with age with a male to female ratio of approximately 5.9:1. Prevalence rates ranged from 0.2% to 56% in varying age, population groups, and methods of data collection. The highest prevalence rate was reported in a study group of epileptic patients. Although, only one study calculated the incidence (as opposed to prevalence) of DD to be equal to 34.3 per 100,000 men (0.03%). In conclusion, the prevalence of DD in different geographical locations is extremely variable, and it is not clear whether this is genetic, environmental, or a combination of both. The majority of the prevalence studies have been conducted in Scandinavia or the UK, and the vast changes in population structure, the changes in prevalence of associated diseases, and the change in diagnostic criteria of DD makes understanding the epidemiology of this condition difficult.
掌腱膜挛缩症（DD）是一种常见的纤维增生性疾病，累及手掌表面，通常不可逆转且呈进行性发展。了解DD的流行病学对于揭示其病因发病机制很重要。本综述旨在评估自1951年以来开展的关于DD的流行病学研究。使用Medline、Pubmed和Scopus检索了1951年至今评估DD流行病学的研究。纳入标准为任何调查任何人群中DD患病率或发病率的研究。共引用了620篇文章。随后确定有49项研究与评估DD的流行病学相关。在所有研究中，DD的患病率随年龄增长而增加，男女比例约为5.9:1。在不同年龄、人群组和数据收集方法中，患病率范围为0.2%至56%。癫痫患者研究组报告的患病率最高。不过，只有一项研究计算出DD的发病率（与患病率相对）为每10万名男性中有34.3例（0.03%）。总之，DD在不同地理位置的患病率差异极大，目前尚不清楚这是由遗传、环境因素还是两者共同作用导致的。大多数患病率研究是在斯堪的纳维亚或英国进行的，而人口结构的巨大变化、相关疾病患病率的变化以及DD诊断标准的变化使得了解这种疾病的流行病学变得困难。
