De Cock H E V, Van Brantegem L, Affolter V K, Oosterlinck M, Ferraro G L, Ducatelle R
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Campus 3 Eiken, D.U 012, Universiteitsplein 1, 2610 Wilrijk, Belgium.
J Comp Pathol. 2009 Feb-Apr;140(2-3):132-9. doi: 10.1016/j.jcpa.2008.10.009. Epub 2009 Jan 14.
Chronic progressive lymphoedema (CPL) in horses, a disease of certain draught breeds, is associated with altered elastin metabolism. The characteristic lesions are seen in the skin of the lower (distal) limbs. This study was based on horses of susceptible breeds, with and without CPL, and on horses of a non-susceptible breed. Skin samples were obtained for examination from the neck (considered a non-affected region) and from the distal limb. The skin lesions were characterized histologically and the dermal elastic fibres were evaluated morphologically and quantitatively. In all horses the mean elastin concentrations were highest in the superficial dermis, gradually decreasing in the mid-dermis and deep dermis. As compared with horses of a non-susceptible breed, affected horses had increased amounts of dermal elastin in both the distal limb and neck, while non-affected horses of a susceptible breed had decreased amounts. The findings support an earlier hypothesis that CPL of horses is a generalized disease. Reduced efficiency of the elastic network in supporting the dermal lymphatics may explain the development of CPL.
马的慢性进行性淋巴水肿（CPL）是某些挽马品种的一种疾病，与弹性蛋白代谢改变有关。特征性病变见于下肢（远端）皮肤。本研究基于易感品种有或无CPL的马以及非易感品种的马。从颈部（被认为是未受影响的区域）和远端肢体获取皮肤样本进行检查。对皮肤病变进行组织学特征分析，并对真皮弹性纤维进行形态学和定量评估。在所有马匹中，弹性蛋白平均浓度在浅表真皮中最高，在真皮中层和深层逐渐降低。与非易感品种的马相比，患病马的远端肢体和颈部真皮弹性蛋白含量增加，而易感品种的未患病马含量减少。这些发现支持了早期的一个假设，即马的CPL是一种全身性疾病。弹性网络在支持真皮淋巴管方面效率降低可能解释了CPL的发生发展。
