de Groote Pascal, Isnard Richard, Clerson Pierre, Jondeau Guillaume, Galinier Michel, Assyag Patrick, Demil Nacima, Ducardonnet Alain, Thebaut Jean-François, Komajda Michel
Pôle de Cardiologie et Maladies Vasculaires, CHRU de Lille, Université de Lille 2, France.
Eur J Heart Fail. 2009 Jan;11(1):85-91. doi: 10.1093/eurjhf/hfn005.
Recent studies have shown that prescription rates and doses of recommended drugs for chronic heart failure (CHF) are not optimal in daily practice. The aim of the Impact-Reco programme was to analyse prescription rates of CHF drugs in stable outpatients with CHF related to left ventricular (LV) systolic dysfunction in two similar surveys in France.
The two surveys, which included 1917 and 1974 patients, were performed between September 2004 to March 2005 and September 2005 to May 2006, respectively. Prescription rates of angiotensin-converting enzyme-inhibitors (ACE-I) remained stable (71 vs. 68%, respectively), whereas the proportion of patients receiving angiotensin receptor blockers (21 vs. 30%, P < 0.0001) and beta-blockers (65 vs. 70% P < 0.0001) increased significantly. Doses of ACE-I and beta-blockers increased significantly between the two surveys. However, the improvement was of lesser magnitude in some subgroups of patients, such as elderly patients or patients with renal failure.
The Impact-Reco programme found an improvement in prescription rates and in the dosage of neurohumoral antagonists in French outpatients with stable CHF. However, there is still room for improvement, especially regarding the doses of medications and the treatment of some subgroups of patients such as the elderly and patients with renal failure.
近期研究表明,在日常实践中,慢性心力衰竭(CHF)推荐药物的处方率和剂量并不理想。Impact-Reco项目的目的是在法国的两项类似调查中,分析与左心室(LV)收缩功能障碍相关的稳定门诊CHF患者中CHF药物的处方率。
这两项调查分别于2004年9月至2005年3月以及2005年9月至2006年5月进行,分别纳入了1917例和1974例患者。血管紧张素转换酶抑制剂(ACE-I)的处方率保持稳定(分别为71%和68%),而接受血管紧张素受体阻滞剂的患者比例(21%对30%,P<0.0001)和β受体阻滞剂(65%对70%,P<0.0001)显著增加。两次调查之间,ACE-I和β受体阻滞剂的剂量显著增加。然而,在一些患者亚组中,如老年患者或肾衰竭患者,改善程度较小。
Impact-Reco项目发现,法国稳定CHF门诊患者中,神经体液拮抗剂的处方率和剂量有所改善。然而,仍有改进空间,特别是在药物剂量以及老年患者和肾衰竭患者等一些患者亚组的治疗方面。