Swillens S, Dumont J E
J Cyclic Nucleotide Res. 1977 Feb;3(1):1-10.
The characteristics of the hormone interaction with their cell receptors and of the related adenylate cyclase activation are complex. Among the theoretical models which have been proposed to account for this mechanism, the mobile or floating receptor model has been discussed (3-5). The purpose of this work is to deduce several particular models from the general mobile receptor model on the basis of thermodynamic considerations. The analysis of some of these models shows that the mobile receptor hypothesis contains in itself the little understood kinetic phenomenon of hormone desensitization.
激素与其细胞受体相互作用以及相关腺苷酸环化酶激活的特性十分复杂。在为解释这一机制而提出的理论模型中，移动或浮动受体模型已被讨论过(3 - 5)。这项工作的目的是基于热力学考量从一般的移动受体模型推导出几个特定模型。对其中一些模型的分析表明，移动受体假说本身包含了尚未被充分理解的激素脱敏动力学现象。
