Varfolomeev S D
Biokhimiia. 1987 Feb;52(2):317-28.
The kinetic regularities of the processes occurring in the system: receptor-adenylate cyclase complex under the effect of a hormone, an agonist or a neuromediator, were studied. Experiments with cell cultures revealed that the effector caused an impulse increase in cAMP and a decrease in the effector-stimulated activity of the adenylate cyclase complex. The above effects were considered within the framework of a kinetic model which takes into account the enzyme complex inactivation in the course of adenylate cyclase synthesis. The data obtained permit to explain the physiological effect of desensitization of the receptor-enzyme system with respect to the effector action as a result of inactivation of this system in the course of the reaction. Possible molecular mechanisms of inactivation are discussed.
研究了在激素、激动剂或神经递质作用下，受体 - 腺苷酸环化酶复合物系统中发生的过程的动力学规律。细胞培养实验表明，效应器导致环磷酸腺苷（cAMP）的脉冲式增加以及腺苷酸环化酶复合物的效应器刺激活性降低。上述效应在一个动力学模型的框架内进行了考量，该模型考虑了腺苷酸环化酶合成过程中酶复合物的失活。所获得的数据有助于解释受体 - 酶系统因效应器作用而脱敏的生理效应，这是该系统在反应过程中失活的结果。文中讨论了失活可能的分子机制。
