Ochsendorf F R, Runne U
Abteilung II, Zentrum der Dermatologie und Venerologie, Klinikum der Universität Frankfurt/Main.
Dtsch Med Wochenschr. 1991 Oct 4;116(40):1513-6. doi: 10.1055/s-2008-1063782.
Owing to a misunderstanding a 26-year-old man took for malaria prevention 2 tablets (1.0 g) chloroquine daily instead of the recommended dose of two tablets weekly. After 2 weeks he developed vertigo, generalized weakness and, after sun-bathing, severe bullous light reaction. After 4 weeks generalized hair depigmentation occurred. Two weeks later abnormal accommodation and double vision set in so that he lost distant and near vision. All these signs disappeared after the drug was discontinued (vertigo, weakness and abnormal accommodation within 2 weeks; hair regrew in normal colour after 8 weeks). This case shows the whole spectrum of subacute chloroquine overdosage.
由于误解，一名26岁男子每日服用2片（1.0克）氯喹用于疟疾预防，而非推荐的每周2片剂量。2周后，他出现眩晕、全身乏力，且在日光浴后出现严重的大疱性光反应。4周后发生全身毛发色素脱失。两周后出现调节异常和复视，导致他丧失了远视力和近视力。停药后所有这些症状均消失（眩晕、乏力和调节异常在2周内消失；8周后毛发重新长出，颜色恢复正常）。该病例显示了亚急性氯喹过量的全部症状。
