Chloroquine overdosage in infancy: a case report.

Increased foreign travel and changes in the prevalence of malaria have made chloroquine more widely prescribed for prophylaxis. It is particularly important to ensure that appropriate doses of chloroquine are administered to children, because even small increases in the therapeutic dose may be toxic. Rapid absorption of the drug from the gastrointestinal tract produces sudden clinical symptoms after overdosage. Cardiac and neurological abnormalities are the most important acute consequences of excess chloroquine.