[八角莲化学成分的研究]
[Studies on chemical constituents of Illicium simonsii].
作者信息
Shang Xiao-Ya, Guo Miao-Ru, Zhao Cong-Wei, Li Shuai
机构信息
Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Arts & Science of Beijing Union University, Beijing 100083, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2490-2.
OBJECTIVE
To study the chemical constituents from the active fractions against HIV in vitro, a crude ethanolic extract of Illicium simonsii.
METHOD
The compounds were isolated with column chromatography methods. MS and NMR spectroscopic methods were used to determine the structures of the compounds.
RESULT
Seven compounds were isolated from the active fractions against HIV in vitro of the 90% ethanol extract and their structures were elucidated as (+)-catechin (1), (-)-epicatechin (2), (+)-catechin 3-O-alpha-L-rhamnopyranoside (3), kaempferol 3-O-alpha-L-rhamnopyranoside (4), quercetin 3-O-alpha-L-rhamnopyranoside (5), erigeside C (6) and daucosterol (7).
CONCLUSION
Seven compounds were isolated from this plant for the first time, but none of them exhibited active against HIV in vitro. Compounds 3 and 6 were isolated from this genus for the first time.
目的
为研究八角莲乙醇粗提物中体外抗HIV活性部位的化学成分。
方法
采用柱色谱法分离化合物。运用质谱和核磁共振光谱法确定化合物结构。
结果
从90%乙醇提取物的体外抗HIV活性部位分离得到7个化合物，其结构分别鉴定为(+)-儿茶素(1)、(-)-表儿茶素(2)、(+)-儿茶素3-O-α-L-鼠李糖苷(3)、山柰酚3-O-α-L-鼠李糖苷(4)、槲皮素3-O-α-L-鼠李糖苷(5)、鹅掌楸苷C(6)和胡萝卜苷(7)。
结论
首次从该植物中分离得到7个化合物，但它们在体外均未表现出抗HIV活性。化合物3和6为首次从该属植物中分离得到。
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