Xu Hui, Lv Min, Tian Xuan
Laboratory of Pharmaceutical Synthesis, College of Science, Northwest A&F University, Yangling 712100, P. R. China.
Curr Med Chem. 2009;16(3):327-49. doi: 10.2174/092986709787002682.
Podophyllotoxin is an important and much sought after antimitotic natural lead compound, since it paved the way for three hemisynthetic derivatives of podophyllotoxin, e.g., etoposide, teniposide and etopophos, which are widely used as anticancer drugs and show good clinical effects against several types of neoplasms. Although the publication of the recent reviews by Gordaliza in 2004 and You in 2005, which covered the literatures concerning podophyllotoxin until the early part of 2003, there have been significant number of works carried out on podophyllotoxin recently. Therefore, this review presents up-to-date coverage of podophyllotoxin in regard to hemisynthesis, biosynthesis, biological activities, mode of action and structure-activity relationship.
鬼臼毒素是一种重要且备受追捧的抗有丝分裂天然先导化合物，因为它为三种鬼臼毒素的半合成衍生物铺平了道路，例如依托泊苷、替尼泊苷和依托泊磷，这些衍生物被广泛用作抗癌药物，对几种类型的肿瘤显示出良好的临床效果。尽管Gordaliza在2004年和You在2005年发表了近期综述，涵盖了截至2003年初有关鬼臼毒素的文献，但最近对鬼臼毒素开展了大量研究工作。因此，本综述提供了鬼臼毒素在半合成、生物合成、生物活性、作用方式和构效关系方面的最新内容。
